全文获取类型
收费全文 | 511篇 |
免费 | 26篇 |
专业分类
电工技术 | 3篇 |
化学工业 | 209篇 |
金属工艺 | 7篇 |
机械仪表 | 18篇 |
建筑科学 | 11篇 |
矿业工程 | 1篇 |
能源动力 | 14篇 |
轻工业 | 109篇 |
石油天然气 | 1篇 |
无线电 | 10篇 |
一般工业技术 | 80篇 |
冶金工业 | 18篇 |
原子能技术 | 1篇 |
自动化技术 | 55篇 |
出版年
2023年 | 5篇 |
2022年 | 6篇 |
2021年 | 59篇 |
2020年 | 18篇 |
2019年 | 18篇 |
2018年 | 13篇 |
2017年 | 16篇 |
2016年 | 18篇 |
2015年 | 16篇 |
2014年 | 18篇 |
2013年 | 42篇 |
2012年 | 33篇 |
2011年 | 41篇 |
2010年 | 36篇 |
2009年 | 32篇 |
2008年 | 42篇 |
2007年 | 21篇 |
2006年 | 17篇 |
2005年 | 17篇 |
2004年 | 12篇 |
2003年 | 3篇 |
2002年 | 6篇 |
2001年 | 7篇 |
2000年 | 8篇 |
1999年 | 5篇 |
1998年 | 4篇 |
1997年 | 1篇 |
1996年 | 3篇 |
1995年 | 4篇 |
1994年 | 4篇 |
1992年 | 3篇 |
1990年 | 4篇 |
1989年 | 1篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
排序方式: 共有537条查询结果,搜索用时 15 毫秒
11.
12.
Depalo Nicoletta Iacobazzi Rosa Maria Valente Gianpiero Arduino Ilaria Villa Silvia Canepa Fabio Laquintana Valentino Fanizza Elisabetta Striccoli Marinella Cutrignelli Annalisa Lopedota Angela Porcelli Letizia Azzariti Amalia Franco Massimo Curri Maria Lucia Denora Nunzio 《Nano Research》2017,10(7):2431-2448
Currently,sorafenib is the only systemic therapy capable of increasing overall survival of hepatocellular carcinoma patients.Unfortunately,its side effects,particularly its overall toxicity,limit the therapeutic response that can be achieved.Superparamagnetic iron oxide nanoparticles (SPIONs) are very attractive for drug delivery because they can be targeted to specific sites in the body through application of a magnetic field,thus improving intratumoral accumulation and reducing adverse effects.Here,nanoformulations based on polyethylene glycol modified phospholipid micelles,loaded with both SPIONs and sorafenib,were successfully prepared and thoroughly investigated by complementary techniques.This nanovector system provided effective drug delivery,had an average hydrodynamic diameter of about 125 nm,had good stability in aqueous medium,and allowed controlled drug loading.Magnetic analysis allowed accurate determination of the amount of SPIONs embedded in each micelle.An in vitro system was designed to test whether the SPION micelles can be efficiently held using a magnetic field under typical flow conditions found in the human liver.Human hepatocellular carcinoma (HepG2) cells were selected as an in vitro system to evaluate tumor cell targeting efficacy of the superparamagnetic micelles loaded with sorafenib.These experiments demonstrated that this delivery platform is able to enhance sorafenib's antitumor effectiveness by magnetic targeting.The magnetic nanovectors described here represent promising candidates for targeting specific hepatic tumor sites,where selective release of sorafenib can improve its efficacy and safety profile. 相似文献
13.
Elisabetta Gavini Giovanna Rassu Giuseppina Sandri Silvia Rossi Andrea Salis 《Drug development and industrial pharmacy》2016,42(4):554-562
AbstractCiprofloxacin is a drug active against a broad spectrum of aerobic Gram-positive and Gram-negative bacteria, for the therapy of ocular infections. It requires frequent administrations owing to rapid ocular clearance and it is a good candidate for ocular controlled release formulations. The preparation of such drug release systems is still a challenge. Ionic interactions between ciprofloxacin and the polyelectrolytes chondroitin sulfate or lambda carrageenan result in coprecipitates that can act as microparticulate controlled release systems from which the drug is released after being displaced by the medium’s ions. In some formulations, Carbopol was added to improve the mucoadhesive properties. The aim of this research was the study of the influence of the technological parameters of the preparation method of coprecipitates on their particle size, with the goal of achieving particles engineered with a size suitable for the ocular administration. Technological parameters taken into account were: concentration of drug and polymer solutions utilized for the preparation of interaction products, possible use of surfactants (kind and concentration), temperature of the solutions and stirring during the process of preparation of the coprecipitates. Preliminary stability study tests were carried out to further characterize the leader formulation. Particle size in suspensions for ocular drug delivery is a critical parameter influencing the quality of the formulation. The results obtained from this study show that chondroitin sulfate coprecipitates present the best characteristics in terms of particle size suitable for ocular administration. A further improvement of the particle size characteristics has been obtained with the addition of surfactants. 相似文献
14.
Interfacing human and computer with wireless body area sensor networks: the WiMoCA solution 总被引:1,自引:0,他引:1
Elisabetta Farella Augusto Pieracci Luca Benini Laura Rocchi Andrea Acquaviva 《Multimedia Tools and Applications》2008,38(3):337-363
Wireless Body Area Sensor Networks (WBASN) are an emerging technology enabling the design of natural human–computer interfaces
(HCI). Automatic recognition of human motion, gestures, and activities is studied in several contexts. For example, mobile
computing technology is being considered as a replacement of traditional input systems. Moreover, body posture and activity
monitoring can be used for entertainment and health-care applications. However, until now, little work has been done to develop
flexible and efficient WBASN solutions suitable for a wide range of applications. Their requirements pose new challenges for
sensor network designs, such as optimizing traditional solutions for use as environmental monitoring-like applications and
developing on-the-field stress tests. In this paper, we demonstrate the flexibility of a custom-designed WBASN called WiMoCA
with respect to a wide range of posture and activity recognition applications by means of practical implementation and on-the-field
testing. Nodes of the network mounted on different parts of the human body exploit tri-axial accelerometers to detect its
movements. The advanced digital Micro-electro-mechanical system (MEMS) based inertial sensor has been chosen for WiMoCA because
it demonstrated high flexibility of use in many different situations, providing the chance to exploit both static and dynamic
acceleration components for different purposes. Furthermore, the sensibility and accuracy of the sensing element is perfectly
adequate for monitoring human movement, while keeping cost low and size compact, thus meeting our requirements. We implemented
three types of applications, stressing the WBASN in many aspects. In fact, they are characterized by different requirements
in terms of accuracy, timeliness, and computation distributed on sensing nodes. For each application, we describe its implementation,
and we discuss results about performance and power consumption.
相似文献
Andrea AcquavivaEmail: |
15.
An experimental comparison of a graphite electrode and a gas diffusion electrode for the cathodic production of hydrogen peroxide 总被引:2,自引:0,他引:2
Anna Da?Pozzo Luca Di?Palma Carlo?Merli Elisabetta?PetrucciEmail author 《Journal of Applied Electrochemistry》2005,35(4):413-419
This work studies the production of hydrogen peroxide through the cathodic reduction of oxygen in acidic medium, by comparing the results obtained using a commercial graphite and a gas diffusion electrode. A low pH was required to allow the application of hydrogen peroxide generation to an electro-Fenton process. The influence of applied potential and the gas flow composition were investigated. The gas diffusion electrode demonstrates a higher selectivity for hydrogen peroxide production, without significantly compromising the iron regeneration, thus making its successful application to a cathodic Fenton-like treatment, possible. Unlike the graphite cathode, the gas diffusion cathode also proved to be effective in the air flow. 相似文献
16.
Cappiello A Famiglini G Palma P Pierini E Termopoli V Trufelli H 《Mass spectrometry reviews》2011,30(6):1242-1255
This review article will give an up-to-date and exhaustive overview on the efficient use of electron ionization (EI) to couple liquid chromatography and mass spectrometry (LC-MS) with an innovative interface called Direct-EI. EI is based on the gas-phase ionization of the analytes, and it is suitable for many applications in a wide range of LC-amenable compounds. In addition, thanks to its operating principles, it prevents unwelcome matrix effects (ME). In fact, although atmospheric pressure ionization (API) methodologies have boosted the use of LC-MS, the related analytical methods are sometime affected by inaccurate quantitative results, due to unavoidable and unpredictable ME. In addition, API's soft ionization spectra always demand for costly and complex tandem mass spectrometry (MS/MS) instruments, which are essential to acquire an "information-rich" spectrum and to obtain accurate quantitative information. In EI a one-stage analyzer is sufficient for a qualitative investigation and MS/MS detection is only used to improve sensitivity and to cut chemical noise. The technology illustrated here provides a robust and straightforward access to classical, well-characterized EI data for a variety of LC applications, and readily interpretable spectra for a wide range of areas of research. The Direct-EI interface can represent the basis for a forthcoming universal LC-MS detector for small molecules. 相似文献
17.
Dr. Vladimir O. Talibov Dr. Edoardo Fabini Edward A. FitzGerald Dr. Daniele Tedesco Daniela Cederfeldt Martin J. Talu Moira M. Rachman Filip Mihalic Dr. Elisabetta Manoni Dr. Marina Naldi Dr. Paola Sanese Dr. Giovanna Forte Dr. Martina Lepore Signorile Prof. Xavier Barril Dr. Cristiano Simone Prof. Manuela Bartolini Dr. Doreen Dobritzsch Dr. Alberto Del Rio Prof. U. Helena Danielson 《Chembiochem : a European journal of chemical biology》2021,22(9):1597-1608
SMYD3 is a multifunctional epigenetic enzyme with lysine methyltransferase activity and various interaction partners. It is implicated in the pathophysiology of cancers but with an unclear mechanism. To discover tool compounds for clarifying its biochemistry and potential as a therapeutic target, a set of drug-like compounds was screened in a biosensor-based competition assay. Diperodon was identified as an allosteric ligand; its R and S enantiomers were isolated, and their affinities to SMYD3 were determined (KD=42 and 84 μM, respectively). Co-crystallization revealed that both enantiomers bind to a previously unidentified allosteric site in the C-terminal protein binding domain, consistent with its weak inhibitory effect. No competition between diperodon and HSP90 (a known SMYD3 interaction partner) was observed although SMYD3–HSP90 binding was confirmed (KD=13 μM). Diperodon clearly represents a novel starting point for the design of tool compounds interacting with a druggable allosteric site, suitable for the exploration of noncatalytic SMYD3 functions and therapeutics with new mechanisms of action. 相似文献
18.
19.
Elisabetta Mangione 《Journal of Adhesion Science and Technology》2019,33(14):1572-1583
This study evaluated the adhesion of resin cements to zirconia after saliva contamination using resin cements with different chemistries. Zirconia discs (N?=?240, n?=?10 per group) were randomly divided into three groups: (a) C: No contamination (Control), (b) S: Contamination with saliva, (c) S?+?AA: Contamination with saliva followed by air-abrasion (CoJet). While half of the specimens were not conditioned, the other half were conditioned with 37.5% H3PO4 for 60?s. After rinsing, all specimen surfaces were silanized (Monobond Plus). Resin cements based on either methacrylate (Variolink II–VL) or MDP monomer (Panavia 21-PN) were polymerized on the substrates. The specimens were randomly divided into two further groups to be tested either after (a) 24?h dry storage at 37?°C or (b) thermocycling (×5000, 5–55?°C). Microshear bond (MSB) tests were conducted in a Universal Testing Machine and failure types were analyzed. Data were analyzed using Univariate analysis and Tukey’s tests (alpha = 0.05). While saliva contamination, 37.5% H3PO4 application (p?<?.001) and aging (p?<?.05) significantly affected the bond results, cement type did not show significant difference after aging (p?>?.05). Adhesive strength of PN (1.2–4.4?MPa) on saliva contaminated and etched zirconia was more stable than that of VL (0–2.8?MPa). After aging, bond strength results decreased the most with VL (3–100%) compared to PN (32–71%) but the decrease was less in the air-abraded groups after aging (VL: 3%; PN: 32%). Exclusively adhesive failures were experienced in all groups. 相似文献
20.
Elisabetta Lambertini Robert L. Buchanan Clare Narrod 《Critical reviews in food science and nutrition》2016,56(3):364-418
Recent Salmonella outbreaks associated with dry pet food and treats raised the level of concern for these products as vehicle of pathogen exposure for both pets and their owners. The need to characterize the microbiological and risk profiles of this class of products is currently not supported by sufficient specific data. This systematic review summarizes existing data on the main variables needed to support an ingredients-to-consumer quantitative risk model to (1) describe the microbial ecology of bacterial pathogens in the dry pet food production chain, (2) estimate pet exposure to pathogens through dry food consumption, and (3) assess human exposure and illness incidence due to contact with pet food and pets in the household. Risk models populated with the data here summarized will provide a tool to quantitatively address the emerging public health concerns associated with pet food and the effectiveness of mitigation measures. Results of such models can provide a basis for improvements in production processes, risk communication to consumers, and regulatory action. 相似文献